The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 14, 1989
Filed:
Apr. 14, 1987
Stephan Buchmann, Munchenstein, CH;
Hans Leuenberger, Pfeffingen, CH;
Claudia Reinke, Freiburg Im Breisgau, DE;
Pharmatronic AG, Pratteln, CH;
Abstract
The system for testing the diffusion behavior of a substance comprises a donor compartment detachably mounted on a holding member of a rotor, rotatably around a vertical axis, said donor compartment being bounded at its bottom by a membrane effective to separate the donor compartment from an acceptor compartment. The membrane comprises a flexible carrier of a bio-compatible, lifeless, light permeable material, on which cells constituting a monocellular layer have been cultivated, for example. By determining the time dependent variation of the quantity of a substance passing through the membrane by diffusion, it is possible to determine the coefficient of diffusion and/or the coefficient of permeability of the membrane and of the cell culture provided thereon. By suitable selection of the cells, conditions may be created that closely resemble those that occur during the absorption of the respective substance through the biophase of a living organism.