The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 28, 1989

Filed:

Aug. 10, 1984
Applicant:
Inventors:

Porter W Anderson, Rochester, NY (US);

John D Clements, New Orleans, LA (US);

Assignee:

Praxis Biologics, Inc., Rochester, NY (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ; A61K / ; C12Q / ; C12N / ; C12N / ; C12N / ;
U.S. Cl.
CPC ...
530403 ; 530807 ; 530812 ; 530808 ; 424 92 ; 435-6 ; 4351723 ; 435320 ; 43524027 ; 935 12 ; 514 12 ;
Abstract

A conjugate, which is the reductive amination product of an immunogenic capsular polymer fragment, having a reducing end and derived from the capsular polymer of a bacterial pathogen, and the non-toxic polypeptide binding subunit of the heat-labile enterotoxin of Escherichia coli (LT-BNT). Also disclosed, are methods for the preparation of the conjugates and for the preparation of vaccines containing the conjugates which elicits an effective level of antibodies in humans. By administering an immunogenic amount of the conjugates, active immunization against systematic infection in young mammals caused by bacterial pathogens can be induced.


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