The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 1989
Filed:
Jun. 29, 1987
Applicant:
Inventors:
Jean Wagnon, Montpellier, FR;
Claude Plouzane, Saint Georges d'Orques, FR;
Bernard Tonnerre, Vailhauques, FR;
Dino Nisato, Saint Georges d'Orques, FR;
Assignee:
Societe Anonyme: Sanofi, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C07B / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
548455 ; 548231 ; 548507 ; 548467 ;
Abstract
The present invention relates to a process for the stereo-specific synthesis of indole derivatives of formula: ##STR1## which consists in using 3-tosyloxy-1,2-O-isopropylidenepropane-1,2-diol (II) in an optically pure form in order to introduce the asymetric carbon C* of compound (I). Compound (II) is condensed with a suitable primary amine in order to prepare an oxazolidinone and condensation with a suitable phenol, and the oxazolidinone ring is then opened to form an indole compound (I).