The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 21, 1989
Filed:
Apr. 14, 1986
Csaba Szantay, Budapest, HU;
Lajos Szabo, Budapest, HU;
Gyorgy Kalaus, Budapest, HU;
Zsolt Szombathelyi, Budapest, HU;
Egon Karpati, Budapest, HU;
Bela Kiss, Vecses, HU;
Katalin Csomor, Budapest, HU;
Istvan Laszlovszky, Budapest, HU;
Erzsebet Lapis, Budapest, HU;
Laszlo Szporny, Budapest, HU;
Lilla Forgacs, Budapest, HU;
Csaba Kuthi, Budapest, HU;
Aniko Gere, Budapest, HU;
Richter Gedeon Vegyeszeti Gyar Rt., Budapest, HU;
Abstract
The invention relates to the new (-)-1.beta.-ethyl-1.alpha.-hydroxymethyl-1,2, 3,4,6,7,12,12b.alpha.-octa-hydroindolo[2,3-a] quinolizine of the formula (I) ##STR1## and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.