The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 24, 1989
Filed:
Nov. 24, 1986
Victor C Yang, Ann Arbor, MI (US);
The University of Michigan, Ann Arbor, MI (US);
Abstract
Heparin in an extracorporeal blood flow circuit is removed from the blood flow with the use of a filter which contains immobilized protamine on a blood-compatible support. In medical procedures where blood is processed in an extracorporeal device, such as an artificial kidney, or a heart-lung machine, the blood is heparinized to prevent clotting thereof in the channels of the extracorporeal device, and the formation of thrombi. In accordance with the invention, the processed, heparinized blood is conducted to a filter arrangement wherein protamine is held immobilized on a support formed of a blood-compatible material. Such an arrangement actually removes heparin from the blood rather than merely negates the anticoagulation effects of the heparin, as is the case in conventional protamine infusion therapy. In the present invention, the extracorporeal blood which is returned to the patient is substantially free of both heparin and protamine. Various chemical mechanisms are presented for activating a polymeric support material so as to bond covalently with the protamine.