The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 08, 1988
Filed:
Mar. 18, 1986
Applicant:
Inventors:
Young S Lo, Richmond, VA (US);
Albert D Cale, Jr, Mechanicsville, VA (US);
Assignee:
A. H. Robins Company, Incorporated, Richmond, VA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
546316 ; 540597 ; 540610 ; 544128 ; 544131 ; 544165 ; 544169 ; 544172 ; 544363 ; 544365 ; 544399 ; 544400 ; 546155 ; 546156 ; 546159 ; 546169 ; 546170 ; 546193 ; 546194 ; 546208 ; 546210 ; 546211 ; 546232 ; 546233 ; 546234 ; 546261 ; 546278 ; 546279 ; 546281 ; 546292 ; 546318 ; 546322 ; 548300 ; 548341 ; 548342 ; 548353 ; 548378 ; 548561 ; 548566 ; 548567 ; 548578 ; 548579 ; 560 21 ; 560 22 ; 560 37 ; 560 61 ; 562435 ; 562437 ; 562442 ; 564166 ; 564184 ;
Abstract
A process for the preparation of 1,4-oxazepinones and thiones having the formula: ##STR1## wherein A is an aromatic ring selected from benzene, naphthalene, quinoline or pyridine; n is 1 to 3; Z is an amino radical; R is hydrogen, loweralkyl, cycloalkyl or phenylloweralkyl; and R.sup.4 and R.sup.5 are hydrogen and loweralkyl starting from chloroaromatic carboxylates and alkanolamines is disclosed. The oxazepinones and oxazepinethiones prepared by the process have utility as antihistaminics with low sedative potential. Novel intermediate compounds are also disclosed.