The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 26, 1988
Filed:
Apr. 22, 1985
Applicant:
Inventor:
Jose Alexander, Lawrence, KS (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C / ; A61K / ; A61K / ; C07D / ;
U.S. Cl.
CPC ...
514187 ; 5142345 ; 5142352 ; 5142358 ; 5142375 ; 514254 ; 514299 ; 514306 ; 514314 ; 514320 ; 514330 ; 514338 ; 514341 ; 514342 ; 514365 ; 514394 ; 514396 ; 514479 ; 514481 ; 514484 ; 514488 ; 544121 ; 544135 ; 544358 ; 544363 ; 544365 ; 546112 ; 546153 ; 546156 ; 546158 ; 546165 ; 546167 ; 546200 ; 548146 ; 548181 ; 548201 ; 548204 ; 560 19 ; 560 24 ; 560 30 ; 560 31 ; 560 32 ; 560 51 ; 560161 ; 560162 ; 560163 ; 560167 ; 560165 ;
Abstract
This invention relates to novel (acyloxyalkoxy)carbonyl derivatives as bioreversible prodrug moieties for primary and secondary amine functions in drugs having a primary or secondary amine function thereon. Hydrolytic enzymes are used to trigger the regeneration of the parent amine drug of the carbamate prodrug moiety. The case also contains pharmaceutical composition, method of treatment and process claims.