The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 1988
Filed:
Jun. 23, 1986
Gabor Megyeri, Budapest, HU;
Tibor Keve, Budapest, HU;
Bala Stefko, Budapest, HU;
Erik Bogsch, Budapest, HU;
Janos Galambos, Budapest, HU;
Anna Kassi nee Zieger, Budapest, HU;
Ferenc Trischler, Budapest, HU;
Eva Palosi, Budapest, HU;
Dora Groo, Budapest, HU;
Egon Karpati, Budapest, HU;
Zsolt Szombathelyi, Budapest, HU;
Laszlo Szporny, Budapest, HU;
Bela Kiss, Vecses, HU;
Istvan Laszlovszky, Budapest, HU;
Erzsebet Lapis, Budapest, HU;
Richter Gedeon Vegyeszeti Gyar Rt., Budapest, HU;
Abstract
The invention relates to a novel process for the preparation of partially new 2-halonicergoline derivatives of the formula (I), ##STR1## wherein X stands for chlorine, bromine or iodine atom, as well as their acid addition salts. The process of the invention comprises esterifying a novel 2-halo-1-methyllumilysergol of the formula (II), ##STR2## wherein X is the same as defined above, or an acid addition salt thereof and, if desired, converting the thus-obtained 2-halonicergoline derivative of the formula (I) to an acid addition salt. The compounds of the invention improve the cognitive function of the brain and show an antihypoxic as well as a strong .alpha.-adrenerg blocking and calcium-antagonistic action.