The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 1988
Filed:
Dec. 19, 1986
Applicant:
Inventors:
W Lawrence Parker, Pennington, NJ (US);
Edward M Cohen, West Windsor Township, Mercer County, NJ (US);
William H Koster, Pennington, NJ (US);
Assignee:
E. R. Squibb & Sons, Inc., Princeton, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ; A61K / ; C07H / ;
U.S. Cl.
CPC ...
514 29 ; 514210 ; 536-72 ; 544355 ;
Abstract
In accordance with the present invention an orally active monosulfactam antibiotics having a crystalline structure and thereby improved stability are disclosed. The antibiotics comprise the dierythromycin (M.sup..sym.=erythromycin.H.sup..sym.) salt or the dicholine (M.sup..sym. =HOCH.sub.2 CH.sub.2 N.sup..sym. (CH.sub.3).sub.3) salt of the acid (M.sup..sym. =H.sup..sym.) having the formula ##STR1## that is, [3S(Z)]-2[[[1-(2-amino-4-thiazolyl)-2-[[2,2-dimethyl-4-oxo-1-(sulfooxy)-3- azetidinyl]-amino]-2-oxoethylidene]amino]oxy]acetic acid.