The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 1988
Filed:
Jun. 26, 1987
Applicant:
Inventors:
Edward L Engelhardt, Gwynedd Valley, PA (US);
Walfred S Saari, Lansdale, PA (US);
Assignee:
Merck & Co. Inc., Rahway, NJ (US);
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; A61K / ; A61K / ;
U.S. Cl.
CPC ...
514327 ; 514328 ; 514331 ; 514424 ; 514245 ; 514428 ; 548543 ; 548544 ; 548546 ; 548550 ; 548556 ; 548567 ; 548569 ; 546232 ; 546233 ; 546235 ; 546220 ; 546221 ;
Abstract
Amides and esters of 2-[N-(hydroxypiperidinoalkyl) and (hydroxypyrrolidinoalkyl) aminosulfonyl]-6-nitrobenzoic acids are disclosed to have activity in increasing the sensitivity of hypoxic tumor cells to therapeutic radiation. Also disclosed are methods of preparing such compounds, pharmaceutical compositions including such compounds and methods of treating patients in need of therapeutic radiation with effective amounts of such compounds.