The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 19, 1988
Filed:
Dec. 23, 1985
Antonin Cerny, Prague, CS;
Jiri Krepelka, Prague, CS;
Milan Melka, Hradec Kralova, CS;
Milan Miko, Bratislava, CS;
Stanislava Pokorna, Prague, CS;
Ruzena Reichlova, Prague, CS;
Irena Kejhova, Prague, CS;
Marta Beitova, Prague, CS;
Jaroslava Grimova, Prague, CS;
SPOFA, Spojene Podniky pro Zdravotnickou Vyrobu, Prague, CS;
Abstract
6-purinyl N-(2-chloroethyl) carbamate and thiocarbamate are disclosed of the general formula I, ##STR1## in which X stands for an oxygen or sulfur atom, and also a process for their preparation by reacting a purine derivative of the general formula II (hypoxanthine or 6-mercaptopurine, respectively) with 2-chloroethylisocyanate. The subject compounds of formula I show a remarkable antineoplastic effect in vitro and in vivo, and consequently have great potential for the treatment of malignant neoplastic diseases in mammals.