The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 22, 1987
Filed:
Feb. 28, 1985
Applicant:
Inventor:
Michael A Palladino, San Mateo, CA (US);
Assignee:
Genentech, Inc., San Francisco, CA (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C12Q / ; C12Q / ; G01N / ;
U.S. Cl.
CPC ...
435 18 ; 424 88 ; 435 29 ; 435 68 ; 4351723 ; 436503 ; 436543 ; 436547 ; 935 60 ; 935 65 ;
Abstract
The in vitro chemotactic activity of recombinant protein compositions is a predictive test for in vivo immunogenicity. Recombinant synthesis methods and subsequent purification or processing techniques are modified in the light of the chemotactic assay results in order to reduce or enhance the in vivo immunogenicity of the compositions. The invention ameliorates a major cost and source of uncertainty in the development of recombinant protein compositions. Immunogenicity of substances in vivo is modulated by binding chemotactic polypeptides thereto.