The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 15, 1987
Filed:
Apr. 25, 1985
Applicant:
Inventors:
Michael N Chang, Westfield, NJ (US);
Kathryn L Thompson, Westfield, NJ (US);
David A Boulton, Edison, NJ (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K / ; C07D / ;
U.S. Cl.
CPC ...
514469 ; 514253 ; 514307 ; 514314 ; 514337 ; 514359 ; 514361 ; 514362 ; 514363 ; 514367 ; 514374 ; 514382 ; 514383 ; 514397 ; 514414 ; 514422 ; 514443 ; 514444 ; 514456 ; 514459 ; 514460 ; 514470 ; 544376 ; 546146 ; 546149 ; 546152 ; 546168 ; 546269 ; 548125 ; 548126 ; 548146 ; 548159 ; 548252 ; 548256 ; 548262 ; 548336 ; 548454 ; 548525 ; 549405 ; 549408 ; 549462 ; 549466 ; 549467 ; 549468 ; 549469 ; 549470 ; 549 57 ; 549 58 ; 549 60 ;
Abstract
Phenylalkyl-2,3-dihydrobenzofurans and analogs were prepared by (1) nucleophilic substitution involving an appropriately substituted 2,3-dihydrobenzofuranol (or 2,3-dihydrobenzopyranol) and a cinnamylhalide followed by reduction; or (2) by Wittig reaction involving a halomethyl derivative of 2,3-dihydrobenzofuran (or 2,3-dihydrobenzopyran and an aryl or a heteroaryl aldehyde followed by reduction. These compounds were found to be potent anti-inflammatory agents.