The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 08, 1987
Filed:
Mar. 29, 1984
Rolf E Axen, Uppsala, SE;
Jan P Carlsson, Uppsala, SE;
Pharmacia Aktiebolag, Uppsala, SE;
Abstract
Therapeutically active organic compound exhibiting at least one radical comprising a structure --S'--S'--R, where S'--R is defined by R being an organic group comprised in a physiologically acceptable compound H--S'--R obtainable by the splitting of the disulfide bridge --S'--S'-- in said structure, in which compound H--S'--R the sulfur atom S' is bound to a carbon atom in a heterocyclic aromatic ring in R having a configuration being such that the compound H--S'--R, while maintaining physiological acceptability, is stabilized, by tautomerism or resonance involving the sulfur atom S' bound to R, so as to be mainly excluded from further reaction involving thiol disulfide exchange; S' being bound to an aliphatic carbon atom; and said compound, in addition to the group or groups comprising the structure --S'--S'--R, also consisting of a residue of a therapeutically active organic base compound of polypeptide structure bound to S', for therapeutical use in mammals, including humans. The invention also relates to a pharmaceutical composition containing as an active substance the compound mentioned above.