The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 1987
Filed:
Jun. 04, 1983
Theodore Jones, Lakewood, CO (US);
Christopher G Rudman, Thousand Oaks, CA (US);
Amgen, Thousand Oaks, CA (US);
Abstract
Disclosed are novel synthetic peptides having primary structural homology to a continuous sequence of amino acid residues of human growth hormone in a region spanning positions thirty-two to forty-six ('hGH.sub.32-46 ', or 'deletion peptide'). In preferred forms, peptides of the invention comprehend: duplicate portions (i.e., sequence fragments) of hGH.sub.32-46 ; stereochemical analogs and fragment analogs of hGH.sub.32-46 including one or more amino acid residues in D-isomeric configuration; and, 'interspecies' analogs and fragment analogs of hGH.sub.32-46 including one or more non-homologous amino acid residues duplicating variant residues present in corresponding positions in corresponding regions of heterologous species growth hormones. Peptides of the invention are administered to mammals contemporaneously with exogenous insulin to generate hypoglycemic effects greater than available through administration of insulin alone. A presently preferred heptapeptide has the sequence, NH.sub.2 -Glu-Glu-Ala-Tyr-Ile-Pro-Lys-COOH, and has insulin-potentiating activity greater than hGH.sub.32-46.