The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 1987
Filed:
Oct. 30, 1985
Robert M Gale, Los Altos, CA (US);
Randall Berggren, Livermore, CA (US);
ALZA Corporation, Palo Alto, CA (US);
Abstract
A medical device and method for the pulsatile administration of a drug through intact skin at a first steady state flux during a first delivery period and a second steady state flux during a second delivery period, said first flux being substantially higher than said second flux; said first and second delivery periods comprising a substantial portion of a predetermined administration period. The device comprises a reservoir of said drug containing an amount of drug sufficient to administer drug at said first and second steady state fluxes during administration period; a reservoir of a skin permeation enhancer for said drug; said reservoir containing an amount of said permeation enhancer sufficient to permit administration of said drug at said first flux only through said first delivery period; and means for maintaining said device on the skin in drug and permeation enhancer transferring relationship thereto a preferred embodiment delivering nitroglycerin and employing ethanol as a permeation enhancer. The device contains means for controlling the maximum delivery rate of one of said drug or enhancer. A preferred embodiment provides for the pulsatile delivery of nitroglycerin.