The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 25, 1987
Filed:
Aug. 29, 1985
Emil T Kaiser, New York, NY (US);
Gonul Velicelebi, San Diego, CA (US);
The Salk Institute for Biological Studies, San Diego, CA (US);
Abstract
Human pancreatic GRF and the hypothalamic GRFs for the human and several other mammalian species were earlier characterized and synthesized. The invention provides synthetic peptides which are potent stimulators of the release of pituitary GH in animals, including humans, and which have the formula: R.sub.1 -R.sub.2 R.sub.3 -Ala-R.sub.5 -R.sub.6 -R.sub.7 -R.sub.8 -R.sub.9 -R.sub.10 -R.sub.11 -R.sub.12 -R.sub.13 -Leu-R.sub.15 -Gln-Leu-R.sub.18 -R.sub.19 -R.sub.20 -R.sub.21 -Leu-Leu-Gln-Glu-R.sub.26 -R.sub.27 -R.sub.28 -Arg-Y wherein R.sub.1 is Tyr, D-Tyr, Met, Phe, D-Phe, Leu, His or D-His, which has either a C.sup.a Me or N.sup.a Me substitution or is unsubstituted; R.sub.2 is Ala or D-Ala; R.sub.3 is Asp or D-Asp; R.sub.5 is Ile or Leu; R.sub.6 is Phe or Tyr; R.sub.7 is Ser or Thr; R.sub.8 is Ser, Asn, Thr or Gln; R.sub.9 is Ala or Ser; R.sub.10 is Tyr, Phe or Leu; R.sub.11 in Arg, Orn or Lys; R.sub.12 is Arg, Orn or Lys; R.sub.13 is Ile, Leu, Phe or Val; R.sub. 15 is Gly or Ala; R.sub.18 is Ala or Ser; R.sub.19 is Ser or Ala; R.sub.20 is Arg, Orn or Lys; R.sub.21 is Arg, Orn or Lys; R.sub.26 is Leu, Ile, Val or Phe; R.sub.27 is Nle, Nva or a natural amino acid; R.sub.28 is Ala, Leu, Asn, Gln, or Ser; and Y is OH or NH.sub.2 ; provided however that at least four of the residues constituting R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, R.sub.10, R.sub.11, R.sub.12, R.sub.13, R.sub.15, R.sub.18, R.sub.19, R.sub.20, R.sub.21 and R.sub.26 are different from the residues appearing in that respective position in the native molecule. These peptides as well as nontoxic salts thereof may be administered to animals, including humans and cold-booded animals, to stimulate the release of GH and may be used diagnostically.