The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 1987
Filed:
Feb. 20, 1985
Johannes Grimmer, Grenaa, DK;
Hans C Horn, Lambshein, DE;
BASF Aktiengesellschaft, Ludwigshafen, DE;
Abstract
Riboflavin of the formula I ##STR1## is prepared by condensation of a 4,5-dimethyl-N-(D)-ribityl-2-phenylazoaniline of the formula II ##STR2## where X is H, --Cl, --NO.sub.2 or --CH.sub.3 in the o- or p-position, with barbituric acid of the formula III ##STR3## in the presence of an acidic condensing agent in an inert organic solvent by an improved process in which the reaction is carried out in an aliphatic diol or triol derivative of the general formula IV ##STR4## where R.sup.1 is H or CH.sub.3, R.sup.2 is H or CH.sub.3 -- or, when n is 0, is CH.sub.3 --CO--O--CH.sub.2 --, R.sup.3 is CH.sub.3 --, C.sub.2 H.sub.5 -- or CH.sub.3 --, R.sup.4 is CH.sub.3 --CO--, or is H when R.sup.3 is CH.sub.3 -- or C.sub.2 H.sub.5 --, and n is 0 or 2, preferably 0, having a boiling point of 80.degree.-180.degree. C., or in a mixture of these as a solvent. In this process, the riboflavin is obtained in particularly pure form and in very good yields.