The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 28, 1987
Filed:
Mar. 10, 1986
Franz Effenberger, Stuttgart, DE;
Jurgen Kuhlwein, Waiblingen, DE;
Karlheinz Drauz, Freigericht, DE;
Degussa Aktiengesellschaft, Frankfurt am Main, DE;
Abstract
There are produced 2-isocyanato-2,3-dehydrocarboxylic acid esters of the general formula: ##STR1## in which R.sup.1 is a straight chain or branched C.sub.1 -C.sub.4 -alkyl group, a phenyl group or a benzyl group, R.sup.2 is hydrogen or a methyl group and R.sup.3 is hydrogen, a straight chain or branched C.sub.1 -C.sub.16 -alkyl group, a C.sub.3 -C.sub.8 -cycloalkyl group, a C.sub.1 -C.sub.6 -alkylmercapto group or a phenyl group by reacting a 2-azido-carboxylic acid ester of the general formula: ##STR2## in an inert solvent at a temperature between 0.degree. and 150.degree. C. with phosgene or diphosgene in the presence of a perrhenate. The compounds of general formula (I) can be converted into the corresponding Z- or BOC-protected 2,3-dehydro-2-amino-carboxylic acid ester with benzyl alcohol or with tert. butyl alcohol, which esters in turn are valuable building blocks for the synthesis of dehydropeptides.