The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 24, 1987
Filed:
Sep. 30, 1983
Robert W Knowles, New York, NY (US);
Bo Dupont, Harrison, NY (US);
Kazuyuki Naito, New York, NY (US);
Yasuo Morishima, Nagoya, JP;
Memorial Sloan-Kettering Institute Cancer Center, New York, NY (US);
Abstract
Two monoclonal antibodies (3-3 and 3-40) were produced which identify two new leukemia associated antigens. Both antibodies reacted with most cell lines derived from patients with T lymphoblastic leukemia (T-ALL), but were not detected on suspensions of normal hematopoietic cells, including thymocytes, by cytotoxicity, absorption of indirect immunofluorescence assays. Analysis of fresh leukemic cells indicated that mAb 3-3 only reacted with T-ALL cells, while mAb 3-40 reacted with some non-T non-B ALL cells and a few acute myelocytic leukemia (AML) cells, as well as T-ALL cells. The 3-40 antigen was also found histopathologically in frozen sections of several normal tissues, including the epithelial cells and a few lymphoid cells of the thymus, and some malignant tissues, while the 3-3 antigen was not found in any tissue studied. A 'double absorption' assay provided additional serological evidence the the two antibodies identify different antigenic determinants. Biochemical analysis indicated that the molecules immunoprecipitated by mAb 3-3 and mAb 3-40 have molecular weights of 35-40,000 daltons. It is demonstrated that the 3-3 and 3-40 antigens are markers for human T-ALL and can be used along with the normal T lymphocyte antigen, 3A1, to discriminate T-ALL from cutaneous T-cell lymphoma (CTCL), adult T cell leukemia (ATL) and T cell chronic lymphocytic leukemia (T-CLL).