The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 20, 1987
Filed:
Mar. 20, 1985
Applicant:
Inventors:
Nobuo Aoki, Tokyo, JP;
Shinichiro Kurosawa, Oklahoma City, OK (US);
Assignee:
Kowa Co., Ltd., Nagoya, JP;
Primary Examiner:
Int. Cl.
CPC ...
C07K / ; C07K / ;
U.S. Cl.
CPC ...
530413 ; 424105 ; 424101 ; 530350 ; 530399 ; 530851 ;
Abstract
A thrombin-binding substance derived from human tissue and having the characteristics of (a) molecular weight: 88,000.+-.20,000 in reduced condition and 71,000.+-.20,000 in unreduced condition; (b) isoelectric point: .sub.p H 4.2.+-.0.5; (c) affinity: strong for thrombin; (d) activities: capable of promoting the thrombin-catalyzed activation of protein C and prolonging clotting time; and (e) stability: stable over a .sub.p H range of 2 to 10 and stable to denaturing agents (sodium dodecylsulfate and urea) and to a pepsin treatment, is effectively useful for thrombolysis and anticoagulation.