The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 14, 1986
Filed:
Apr. 12, 1982
Thomas J Bardos, Snyder, NY (US);
Michael E Perlman, Amherst, NY (US);
The Research Foundation of State University of New York, Albany, NY (US);
Abstract
Novel phosphoaziridines of the formula: ##STR1## wherein Z is oxygen or sulfur, R.sub.1 is independently at each occurrence H or --CH.sub.3, R.sub.2 is independently at each occurrence --CH.sub.3 or nitrophenyl R.sub.5 ; R.sub.3 is --NHR.sub.4, --OR.sub.4, --SR.sub.4 or ##STR2## where R.sub.4 is a radical containing up to 30 atoms including at least one amine, ester, ether, alkyl, substituted alkyl, hydrogen, phenyl, substituted phenyl, carbamate, heterocyclic ring or R.sub.5 group; provided that, when R.sub.4 contains and R.sub.5 group, R.sub.4 has an alkyl group between the phosphorous and the R.sub.5 group; and R.sub.5 is a radical containing and electron affinic group comprising a quinone, or a heterocyclic or phenyl ring directly connected to a radical selected from the group consisting of nitro, nitroso, sulfinyl, sulfoxine, and N-oxide; provided that the compound contains at least one R.sub.5 radical and provided that when R.sub.1 is H, the R.sub.2 group on the same ring is R.sub.5 ; and the method for using the above compounds for the treatment of tumors.