The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 16, 1986
Filed:
Jun. 11, 1985
Jaroslav Drobnik, Prague, CS;
Helena Stepankova, Prague, CS;
Ceskoslovenska akademie Ved, Prague, CS;
Abstract
The invention pertains to a biodegradable implant formed from a gel completely decomposable in body, which contains the antitumour medical - diamminedichloroplatinum addition compound (cisplatin) and to a method for preparation of this implant. An object of the invention is a biodegradable implant, wherein a matrix of the said implant is formed by a starch gel containing 0.2 to 2 wt. % NaCl, plasticized by addition of 1 to 30 wt. % of glycerol, suitably shaped, and contains the homogeneously dispersed microcrystalline cisplatin in the amount of 1 to 15 wt. %. A method for preparation the implant according to the invention consists in a homogeneous mixing of 1 wt. part of a viscous aqueous solution, obtained by dissolution of 0.4 to 4 wt. % NaCl and conversion of 1 to 6 wt. % of starch to a paste by boiling, with 0.1 to 0.8 wt. parts of glycerol, 0.5 to 1 wt. part of starch, and the required amount of microcrystalline cisplatin, deaeration of the mixture, conversion to a gel in a mould determining the final shape of implant by heating in a boiling-water bath, and, eventually, in hardening by soaking in a water-miscible solvent, advantageously in acetone or ethanol. An advantage of the implant according to the invention consists in a relatively fast release of cisplatin into surroundings, which is desirable with respect to the mechanism of cisplatin action. Another advantage is the degradability of implant to products natural for body, which have not toxicologic nor immunologic importance.