The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 02, 1986
Filed:
Nov. 14, 1983
Applicant:
Inventors:
Melvin H Keyes, Sylvania, OH (US);
Saraswathi Vasan, Toledo, OH (US);
Assignee:
Owens-Illinois, Inc., Toledo, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C12N / ; C07K / ; C07K / ;
U.S. Cl.
CPC ...
435176 ; 435177 ; 435178 ; 435180 ; 435181 ; 435188 ; 435183 ; 435196 ; 435233 ; 435234 ; 525 541 ; 530815 ; 530402 ;
Abstract
A process is disclosed for chemically modifying naturally occurring proteins to produce enzyme-like modified proteins. The process comprises partially denaturing a cofactor containing holoprotein by removal of the cofactor to produce a partially denatured cofactorless or so-called apoprotein. The partially denatured protein is contacted with an inhibitor of a selected model enzyme and cross-linked. The resultant protein product is an enzyme-like modified protein having the catalytic characteristics of the model enzyme whose inhibitor is contacted with the partially denatured apoprotein.