The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 03, 1986
Filed:
Dec. 24, 1984
Tsutomu Irikura, Tokyo, JP;
Koichi Takagi, Omiya, JP;
Shizuyoshi Fujimori, Nogi, JP;
Yoshihiro Hirata, Omiya, JP;
Kyorin Pharmaceutical Co., Ltd., Tokyo, JP;
Abstract
The invention provides a novel spiro-linked pyrrolidine-2,5-dione of the formula; ##STR1## wherein X.sub.1 and X.sub.2 each independently represent a hydrogen, a halogen atom, a lower alkyl or lower alkoxy group; Y is a methylene group, oxygen or sulfur atom; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each independently represent a hydrogen atom, a lower alkyl group or forming a benzene ring together with their adjacent carbon atoms; the base salts thereof with pharmaceutically acceptable cations, and processes for their manufactures. The compounds of formula [I] useful as aldose reductase inhibitors and as therapeutic agents for treatment of chronic diabetic complications are also disclosed.