The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 20, 1986
Filed:
Jul. 25, 1984
Degussa Aktiengesellschaft, Frankfurt am Main, DE;
Abstract
Thin-layer chromatography is employed to separate enantiomers of the general formula, ##STR1## in which C* represents an asymmetric center and the substituents R.sup.1, R.sup.2, and R.sup.3 are such that they supply the structural element ##STR2## for .alpha.-amino- or .alpha.-iminocarboxylic acids, particularly the well-known .alpha.-amino- or .alpha.-iminocarboxylic or for derivatives of such carboxylic acids, either of which contains no free thiol groups. In the thin-layer chromatographic separation operation a TLC plate is used which is coated with silica gel hydrophobicized by a silane derivative and which is further impregnated with an ionic compound of a divalent transition metal and a chiral selector. The mobile phase employed is a ternary mixture of a water-miscible alkanol, such as methanol, water, and acetonitrile, or a quaternary mixture of the latter ternary mixture to which a water-miscible cyclic ether, such as tetrahydrofuran, has been added.