The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
May. 06, 1986

Filed:

Apr. 01, 1982
Applicant:
Inventors:

Hermann Breuer, Schoenhofen, DE;

William A Slusarchyk, Belle Mead, NJ (US);

Theodor Denzel, Regensburg, DE;

Uwe D Treuner, Regensburg, DE;

Assignee:

E. R. Squibb & Sons, Inc., Princeton, NJ (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; A61K / ;
U.S. Cl.
CPC ...
2602 / ; 2602 / ; 544333 ; 544334 ; 2602433 ; 544359 ; 544364 ; 2602444 ; 544366 ; 544369 ; 2602454 ; 544370 ; 544371 ; 2602455 ; 544372 ; 544367 ; 2602456 ; 544374 ; 544379 ; 2602457 ; 546187 ; 546193 ; 2603303 ; 546194 ; 546207 ; 2603304 ; 546209 ; 546210 ; 544182 ; 546211 ; 546212 ; 544215 ; 546213 ; 546256 ; 544279 ; 546275 ; 546276 ; 544295 ; 546278 ; 546279 ; 544296 ; 546280 ; 546281 ; 544300 ; 546283 ; 546284 ; 544301 ; 544310 ; 544311 ; 544312 ; 544316 ; 544317 ; 544319 ; 544320 ; 544321 ; 544322 ; 544323 ; 544324 ; 544325 ; 544326 ; 544327 ; 544331 ; 544332 ;
Abstract

Antibacterial activity is exhibited by .beta.-lactams having a ##STR1## substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur, and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (R.sub.c), phenylalkyl, (substituted phenyl)alkyl, R.sub.c -alkyl or --NR.sub.a R.sub.b wherein R.sub.a and R.sub.b are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, or (substituted phenyl)alkyl or one of R.sub.a and R.sub.b is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino, alkanoylamino, arylcarbonylamino, alkoxycarbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)amino, hydroxy, cyano, alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, R.sub.c, R.sub.c -alkyl, R.sub.c -alkoxy, alkylsulfonyl, alkylmethyleneamino, phenylmethyleneamino or (substituted phenyl)methyleneamino.


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