The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 01, 1986
Filed:
Apr. 27, 1984
Kalman Harsanyi, Budapest, HU;
Gyorgy Domany, Budapest, HU;
Oszkar Fuchs, Dunakesz, HU;
Lajos Toldy, Budapest, HU;
Gyorgy Fekete, Budapest, HU;
Endre Kasztreiner, Budapest, HU;
Bela Hegedus, Budapest, HU;
Ferenc Morasz, Budapest, HU;
Andras Rado, Budapest, HU;
Tibor Lang, Budapest, HU;
Arpad Lazar, Budapest, HU;
Eva Csongor, Budapest, HU;
Tibor Balogh, Budapest, HU;
Janos Borvendeg, Budapest, HU;
Jozsef Reiter, Budapest, HU;
Tibor Somogyi, Budapest, HU;
Margit Bidlo nee Igloy, Budapest, HU;
Richter Gedeon Vegyeszeti Gyar Rt., Budapest, HU;
Abstract
The invention relates to the new monohydrate of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne (cimetidine), a histamine-H.sub.2 receptor antagonist which is called N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne H (cimetidine H) as well as to a process for the preparation of same, which comprises pouring a hot, homogeneous aqueous solution of N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne, optionally containing also methylamine, onto ice and separating the N-methyl-N'-{2-[(5-methylimidazol-4-yl)-methylthio]-ethyl}-N'-cyanoguanidi ne monohydrate.