The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 12, 1985
Filed:
Apr. 09, 1984
Jurgen Grob, Giebenach, CH;
Jaroslav Kalvoda, Binningen, CH;
Ciba Geigy Corporation, Ardsley, NY (US);
Abstract
(5.alpha.)-20-spirox-1-en-3-ones (I) and 17-hydroxy-5.alpha.,17.alpha.-pregn-1-en-3-ones (II) of the formulae ##STR1## in which X represents O or H.sub.2, R.sub.2 represents O and R.sub.1 represents OH, OMe, OAlk, NH.sub.2, NHR.sub.3, NR.sub.3 R.sub.4, or R.sub.2 represents H.sub.2 and R.sub.1 represents OH, OAlk, OAr, OAralk or OAc, in which R.sub.3, R.sub.4 and Alk represent lower alkyl, Me represents a metal atom or metal equivalent or the cation of an organic base, Ar represents monocyclic aryl, Aralk represents monocyclic aryl-lower alkyl, and Ac represents lower alkanoyl, monocyclic aroyl, lower alkylsulphonyl or monocyclic arylsulphonyl, it being possible for R.sub.3 together with R.sub.4 also to represent a lower alkylene group optionally interrupted by a hetero atom, are manufactured by known analogy processes. They exhibit an aldosterone-antagonistic action and can therefore be used, for example, as potassium-conserving diuretics, optionally together with another electrolyte-non-specific diuretic or saluretic.