The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 29, 1985
Filed:
Jan. 19, 1983
Jeffrey J Barlow, Stockport, GB;
Leslie H Smith, Cheadle, GB;
Imperial Chemical Industries plc, London, GB;
Abstract
Alkanolamine derivatives of the formula ##STR1## wherein Ar is phenyl or napthyl which is unsubstituted or which bears one or two defined substituents, or Ar is certain defined heterocyclic or bicyclic aromatic systems; wherein R.sup.1 is halogen, cyano, trifluoromethyl or trifluoromethylthio; wherein either R.sup.2 and R.sup.3 each is hydrogen or alkyl, or R.sup.2 is hydrogen and R.sup.3 is cycloalkyl or cycloalkyl-alkyl, or R.sup.2 and R.sup.3 are joined to form, together with the adjacent nitrogen atom, a heterocyclic group; wherein either R.sup.4 is hydrogen and R.sup.5 is hydrogen or alkyl, or R.sup.4 is hydrogen and R.sup.5 and R.sup.6 are joined together to form alkylene, or R.sup.4, R.sup.5 and R.sup.6 are joined together to form alk-1-yl-.omega.-ylidene; wherein either R.sup.6 and R.sup.7 each is hydrogen or alkyl, or R.sup.6 is joined to R.sup.4 or to R.sup.4 and R.sup.5 as defined above and R.sup.7 is hydrogen or alkyl, or R.sup.6 and R.sup.7 are joined together to form alkylene, or one of R.sup.6 and R.sup.7 is hydrogen or alkyl and the other of R.sup.6 and R.sup.7 is joined to A as defined below; and wherein either A is alkylene, cycloalkylene or cycloalkylene-alkylene, or wherein A together with either R.sup.6 and its accompanying nitrogen atom, or R.sup.7 and its accompanying nitrogen atom, form pyrrolidine-diyl or piperidine-diyl; and acid-addition salts thereof; processes for their manufacture and pharmaceutical compositions containing them. The compounds possess .beta.-adrenergic blocking and/or diuretic activity.