The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 01, 1985
Filed:
Sep. 07, 1982
Anna Szabolcs nee Borbas, Budapest, HU;
Laszlo tvos, Budapest, HU;
Janos Sagi, Budapest, HU;
Attila Szemzo, Budapest, HU;
Maria Peredy nee Kajtar, Budapest, HU;
Istvan Horvath, Budapest, HU;
Istvan Koczka, Budapest, HU;
Csilla Rethati, Budapest, HU;
Pal Ivan, Budapest, HU;
Ildiko Fritzsche nee Lukacs, Budapest, HU;
Janos Nagy, Budapest, HU;
Egyt Gyogyszervegyeszeti Gyar, Budapest, HU;
Abstract
The invention relates to (E)-5-(2-bromovinyl)-uridine and its derivatives of general formula VI, ##STR1## wherein R.sup.1 stands for a hydrogen atom, C.sub.1-8 alkanoyl group, benzoyl group or a benzoyl group substituted in para position either with a C.sub.1-4 alkyl group or a halogen atom, and a process for preparing them by brominating 2',3',5'-tri-O-acyl-5-ethyl-uridine of general formula IV, ##STR2## wherein R is identical with R.sup.1, except where R.sup.1 stands for a hydrogen atom, dehydrohalogenating the resulting dibromo compound of general formula V ##STR3## and optionally deacylating it. The resulting compounds of general formula VI are exhibiting significant potency against Herpes simplex virus species and are of remarkably low acute toxicity.