logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 4542233 B1

PDFFull Text
Date of Patent:
Sep. 17, 1985

Filed:

Jul. 20, 1983

Process for preparing biaryl compounds via coupling of an arylamine with

Applicant:
Inventors:

Oreste Piccolo, Leghorn, IT;

Aldo Belli, Cornate D'Adda, IT;

Giovanni Villa, Monticello, IT;

Enrico Zen, Macherio, IT;

Attilio Citterio, Monza, IT;

Assignee:

Biaschim S.p.A., Milan, IT;

Attorney:

Cushman, Darby & Cushman

Primary Examiner:

Natalie Trousof

Assistant Examiner:

Vera C Clarke

Int. Cl.
CPC ...
C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ; C07C / ;
U.S. Cl.
CPC ...
560 21 ; 2604 / ; 2604 / ; 560-9 ; 560 17 ; 560 51 ; 560 52 ; 560 54 ; 560 59 ; 560 81 ; 560 82 ; 562431 ; 562435 ; 562460 ; 562463 ; 562469 ; 562488 ; 568 58 ; 568 63 ; 568 66 ; 568 68 ; 568306 ; 568312 ; 568315 ; 568316 ; 568424 ; 568433 ; 568585 ; 568586 ; 568631 ; 568635 ; 568636 ; 568637 ;
Abstract

Improvement in the process for preparing biaryl compounds via coupling of an arylamine with an arene in the presence of a nitrite, an acid and copper metal or a derivative thereof; the improvement is consisting in adding to the reaction mixture a trialkylorthoformate. The process may be used for preparing drugs such as Flurbiprofen and Xenbucin or intermediate compounds particularly useful for preparing Flurbiprofen, Flufenisal, Chlordimorin, Xenbucin, Xenysalate, Xenyhexenic acid and the like.

Find Patent Forward Citations

Piccolo, Oreste. (1985). Process for preparing biaryl compounds via coupling of an arylamine with (U.S. Patent No. 4542233). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/4542233

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…