The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 23, 1985
Filed:
Dec. 15, 1983
Commissariat a l'Energie Atomique, Paris, FR;
Abstract
The invention relates to novel peptide derivatives, their preparation process and their pharmaceutical use. These derivatives are in accordance with the following formula: ##STR1## in which A stands for hydrogen, a radical derived from an amino acid, a group of formula DE in which D represents the N-t-butyloxycarbonyl (BOC), tertamyl-oxycarbonyl (tAOC), N-benzyloxycarbonyl, N-benzoyl, N-acetyl, N-pivaloyl, N-carbamoyl, or N-succinyl radical, and E stands for a single bond or a radical derived from an amino acid which is either not substituted or substituted by HSO.sub.3 or a peptide formed from 2 to 5 amino acids, either unsubstituted or substituted by HSO.sub.3 ; B represents the L-methyonyl, D-methionyl, L-norleucyl, D-nodeucyl, L-leucyl, D-leucyl, L-norvalyl or D-norvalvyl radical; Y represents H, CH.sub.2 OH, COOR.sup.1 with R.sup.1 representing hydrogen or an allyl radical in C.sub.1 and C.sub.4 or CO--NHR.sup.2 with R.sup.2 representing hydrogen, an alkyl radical in C.sub.1 and C.sub.4 or NH.sub.2 ; m is an integer between 0 and 6 and X represents an amino derivative having at least 5 carbon atoms and a pentagonal unsaturated heterocycle. They are usable as antagonists of gastrin and histamine.