The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 28, 1985
Filed:
Sep. 17, 1984
Takashi Hirano, Sakura, JP;
Shinichi Ohashi, Sakura, JP;
Satoshi Morimoto, Yatabe, JP;
Masaru Shiraki, Sakura, JP;
Keishiro Tsuda, Sakura, JP;
Tomowo Kobayashi, Tokyo, JP;
Shigeru Tsukagoshi, Tokyo, JP;
Abstract
The novel polymeric compound proposed in the invention has a backbone structure formed of a copolymeric moiety of maleic anhydride and divinyl ether and pendant groups thereon derived from an anthracycline-type anti-tumor agent, e.g. adriamycin and daunomycin, or 1-.beta.-D-arabinofuranosylcytosine bonded to the maleic anhydride units in the backbone structure by forming amide linkages, the remaining anhydride units in the backbone structure being hydrolyzed into free acid form or a salt thereof. Both in vitro and in vivo tests indicate that the anti-tumor active pendant groups in the polymeric compound can be released sustainedly to exhibit the anti-tumor activity with greatly decreased side effects unavoidable when the above mentioned anti-tumor agents as such are administrated to a patient in a relatively large dose.