The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 1985
Filed:
May. 01, 1981
Akio Sato, Yatabemachi, JP;
Kenji Nakajima, Yatabemachi, JP;
Yoshimasa Takahara, Yatabemachi, JP;
Shizumasa Kijima, Niiza, JP;
Yuichi Inai, Tokyo, JP;
Yoshiyuki Kohara, Gifu, JP;
Yoshiyuki Kawakami, Tokyo, JP;
Tomio Tsurugi, Gifu, JP;
Eisai Co., Ltd., Tokyo, JP;
Agency of Industrial Science & Technology, Tokyo, JP;
Abstract
Polyprenyl carboxylic acid derivatives having the general formula (I): ##STR1## in which n is an integer of from 2 to 4, R.sub.1 represents the hydrogen atom or a protecting group for the carboxylic acid group, and R.sub.2 represents a hydroxymethyl, formyl or carboxyl group, are disclosed. A process for the preparation of the polyprenyl carboxylic acid derivative involving microbiological oxidation using a strain belonging to the genus Nocardia is disclosed. The compounds have anti-ulcer activity and hypotensive activity. The compounds also are useful as intermediates for preparing polyprenyl carboxylic acids of the formula ##STR2## and esters thereof, wherein l is an integer of from 4 to 11. The polyprenyl carboxylic acids and esters thereof have hypotensive activity and anti-ulcer activity.