The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 19, 1985
Filed:
Dec. 27, 1982
Applicant:
Inventors:
Wayne A Spitzer, Indianapolis, IN (US);
Theodore Goodson, Jr, Indianapolis, IN (US);
Assignee:
Eli Lilly and Company, Indianapolis, IN (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; C07D / ; C07D / ; C07B / ;
U.S. Cl.
CPC ...
2602 / ; 2602454 ; 2603303 ; 2603309 ; 546208 ;
Abstract
4-Fluoroazetidinone antibacterial agents are provided by a process comprising the reaction of an azetidinone-4-sulfinic acid, or a salt thereof, with perchloryl fluoride (FClO.sub.3) at -80.degree. C. to -25.degree. C., e.g., p-nitrobenzyl 3-methyl-2-(2-oxo-4-sulfino-3-phenoxyacetamido-1-azetidinyl-3-butenoate is reacted with FClO.sub.3 to provide corresponding 4-fluoroazetidinone. The latter is isomerized with a tertiary amine to corresponding 2-butenoate which a carboxy group deprotection provides an antibacterial compound.