The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 11, 1984
Filed:
Jan. 03, 1983
Applicant:
Inventors:
Mark G Bock, Hatfield, PA (US);
Robert M DiPardo, Lansdale, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
562567 ; 560160 ; 560170 ; 548215 ;
Abstract
4-Amino-3-hydroxy-2,4-(disubstituted)pentanoic acids of the formula: ##STR1## useful as intermediates in preparing antibacterial compounds, are synthesized enantiospecifically by acylation of a chiral enolate with an optically active acylating agent. The resulting product is reduced stereospecifically to afford a protected form of the desired product, which contains three adjacent asymmetric centers of known configuration. The synthesis may be illustrated as follows: ##STR2##