The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 27, 1984
Filed:
Jun. 11, 1982
Applicant:
Inventors:
Assignee:
University Patents, Inc., Norwalk, CT (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07C / ;
U.S. Cl.
CPC ...
2601 / ;
Abstract
Cyclic analogues of the tridecapeptide hormone, .alpha.-melanotropin. (.alpha.-melanocyte stimulating hormone, .alpha.-MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino acid residue at position 10 or 11, and/or (2) between the amino acid residue at position 5 and an amino acid residue at position 10 or 11. Preferred analogues, e.g., [half-Cys.sup.4, half-Cys.sup.10 ]-.alpha.-MSH display greatly increased in vitro potency, prolongation, and resistance to enzymatic degradation.