The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 11, 1984
Filed:
Dec. 30, 1981
Applicant:
Inventors:
Barbara M Iglewski, Portland, OR (US);
Stanley J Cryz, Jr, Bolligen, CH;
Assignee:
Other;
Primary Examiner:
Int. Cl.
CPC ...
C07G / ; A61K / ; C12P / ; C12N / ;
U.S. Cl.
CPC ...
2601 / ; 424 88 ; 424 92 ; 435 68 ; 435253 ;
Abstract
A nontoxic, immunologically crossreactive toxin A protein produced by a PAO-PR1 mutant strain of Pseudomonas aeruginosa. The protein, in activated form, has substantially no adenosine diphosphate-ribosylating activity, and is nontoxic to cells known to be susceptible to the parent PAO-1 strain of Pseudomonas aeruginosa from which strain PAO-PR1 was derived. The nontoxic toxin A protein is immunologically indistinguishable from, and has a molecular weight similar to, native toxin A protein produced by the PAO-1 strain.