The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 04, 1984
Filed:
Mar. 10, 1983
Hamao Umezawa, Tokyo, JP;
Sumio Umezawa, Tokyo, JP;
Tsutomu Tsuchiya, Yokohama, JP;
Tetsuo Shitara, Tokyo, JP;
Shuichi Sakamoto, Kodaira, JP;
Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai, Tokyo, JP;
Abstract
New semi-synthetic antibiotics, 3'-epistreptomycin and 3'-epidihydrostreptomycin are now provided, which are useful as antibacterial agents. 3'-Epidihydrostreptomycin is produced by a process comprising hydrolyzing an appropriately N,O-protected 2',3'-N,O-carbonyl-3'-epidihydrostreptomycin which is prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures into dihydrostreptomycin and intermolecular condensation of a particular pair of amino-protecting and hydroxyl-protecting groups so introduced. 3'-Epistreptomycin is produced by a process comprising oxidizing the 3'-hydroxymethyl group of an appropriately N,O-protected 3'-epidihydrostreptomycin as prepared by skilled introduction of amino-protecting groups and hydroxyl-protecting groups of appropriately selected natures, and then removing the remaining protective groups from the resultant N,O-protected 3'-epistreptomycin obtained as the oxidation product.