The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 17, 1984
Filed:
Jan. 12, 1983
Takehisa Ohashi, Kobe, JP;
Masami Shimazaki, Takasago, JP;
Kenji Nomura, Akashi, JP;
Yasushi Nose, Takasago, JP;
Kiyoshi Watanabe, Akashi, JP;
Kanegafuchi Chemical Industry Company, Ltd., Osaka, JP;
Abstract
An improved process for preparation of an optically active N-(3-mercapto-2-D-methylpropanoyl)-L-amino acid represented by formula (I): ##STR1## from an N-(3-chloro-2-D-methylpropanoyl)-L-amino acid represented by formula (II): ##STR2## (Y in (I) and (II): CH.sub.2 or sulfur; Q in (II): hydrogen, Na, K or NH.sub.4), which is characterized by reacting the compound (II) with an alkali trithiocarbonate, of which the molar ratio to the compound (II) is not less than 1.5, in an aqueous medium at a temperature of from about 60.degree. C. to about 90.degree. C., and hydrolyzing the resulting product with an acid. It is preferable to use sodium trithiocarbonate as the alkali trithiocarbonate, mineral acid as the acid, or water or aqueous alcohol as an aqueous medium.