The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 08, 1984
Filed:
Jun. 04, 1982
Baldomero M Olivera, Salt Lake City, UT (US);
Lourdes J Cruz, Sta Mesa, Manila, PH;
William R Gray, Salt Lake City, UT (US);
Jean E Rivier, La Jolla, CA (US);
Other;
Abstract
The present invention provides bioactive peptides of generic formula ##STR1## These peptides are extremely potent inhibitors of synaptic transmission at the neuromuscular junction, while at the same time lacing demonstrable inhibition of either nerve or muscle action potential propagation. The peptides are termed conotoxins herein. Naturally occurring conotoxins include conotoxin GI, GIA and GII. In conotoxin GI, U is Glu, V.sub.4 is Asn, V.sub.5 is Pro, V.sub.6 is Ala, W is Gly, X is Arg, Y is His, Z is Tyr, V.sub.12 is Ser and R is --NH.sub.2. Conotoxin GIA is identical to GI except R is --Gly--Lys--NH.sub.2. Conotoxin GII is identical to GI except that V.sub.4 is His, Z is Phe, and X is Lys. Conotoxin MI is identical to GI except that U is Gly-Arg, X is Lys and Y is Asn.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile