The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 14, 1984
Filed:
Oct. 09, 1981
Cesare Mondadori, Don Mills, CA;
Markus Schmutz, Basel, CH;
Ciba-Geigy Corporation, Ardsley, NY (US);
Abstract
The present invention relates to novel pharmaceutical compositions having antiepileptic and antineuraglic action and containing (a) at least one anticonvulsive compound of the general formula I ##STR1## wherein X.sub.1 is hydrogen, halogen having an atomic number up to 35, or is cyano, and X.sub.2 and Y together are an additional bond, or X.sub.1 and X.sub.2 together are the oxo radical, or X.sub.1 is hydroxy, X.sub.2 is hydrogen and Y is also hydrogen, and (b) at least one nootropic compound of the vincamine type which has the general formula II ##STR2## wherein Z.sub.1 is lower alkoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, or Z.sub.2 and Z.sub.3 together are an additional bond, or one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is also hydrogen, in particular vincamine (DCI rec.), in which Z.sub.1 is methoxycarbonyl, Z.sub.2 is hydroxy and Z.sub.3 is hydrogen, and also e.g., vinpocetin (DCI rec.), in which Z.sub.1 is ethoxycarbonyl and Z.sub.2 and Z.sub.3 together form an additional bond, as well as vincanol (DCI prop.), in which one of Z.sub.1 and Z.sub.2 is hydroxy and the other is hydrogen and Z.sub.3 is hydrogen, and the acid addition salts thereof, or at least one nootropic derivative of 2-pyrrolidinone, e.g. 2-oxo-1-pyrrolidineaetamide (piracetam) or one of its nootropic derivatives. The compounds of the general formula II e.g. vincamine, as well as the nootropic derivatives of 2-pyrrolidinone, e.g. piracetam, have in themselves virtually no anticonvulsive activity but potentiate the action of the compounds of the general formula I, e.g. carbamazepine.