The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 31, 1984
Filed:
Mar. 15, 1982
Applicant:
Inventors:
Richard L Tolman, Warren, NJ (US);
Stephen Marburg, Metuchen, NJ (US);
Lynn T Callahan, III, North Wales, PA (US);
Assignee:
Merck & Co., Inc., Rahway, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07C / ;
U.S. Cl.
CPC ...
424 87 ; 424 92 ; 424 85 ; 424 88 ; 2601 / ; 536 26 ;
Abstract
ADP-ribosylating toxins are rendered exzymatically inactive by reactions with photolabile affinity reagents. The toxoids retain the antigenic and immunogenic properties of the original toxins. These bacterial toxoids can be used as immunogens to protect against the specific disease that the precursor toxins cause or, in the case of P. aeruginosa, the toxiod can be used in combination with E. coli J-5 vaccine to protect against gram-negative bacteremia in general.