The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 03, 1984
Filed:
Feb. 03, 1982
Michel Biollaz, Riehen, CH;
Ciba-Geigy Corporation, Ardsley, NY (US);
Abstract
The present invention relates to a novel general process for synthesizing a .alpha.- or .beta.-oriented hydroxyacetyl side chain of steroids of the pregnane type, which comprises treating a corresponding steroid carbaldehyde in succession with formaldehyde dimethylmercaptal-S-oxide in the form of an alkali metal salt thereof, and with a strongly acid hydrolysing agent. Preferred final products are compounds of the formula ##STR1## wherein n is 1 or 2, R.sup.2 represents methyl or difluoromethyl, and R.sup.1 represents hydroxymethyl, methoxymethyl, acetoxymethyl or hydrogen, and, if n is 2 and/or R.sup.2 is difluoromethyl, R.sup.1 also represents methyl. These compounds act as agonists or antagonists of natural steroid hormones. The antigestagenic 19,21-dihydroxy-17.alpha.-pregn-4-ene-3,20-dione and its 6,7-dehydro derivatives and diacetates are of particular interest.