The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 04, 1983

Filed:

Aug. 10, 1982
Applicant:
Inventors:

Claude Cotrel, Paris, FR;

Daniel Farge, Thiais, FR;

Gerard Taurand, Sucy-en-Brie, FR;

Assignee:

Rhone-Poulenc Sante, Courbevoie, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K / ; A61K / ; C07D / ; C07D / ;
U.S. Cl.
CPC ...
424246 ; 42424851 ; 424250 ; 424263 ; 424267 ; 424274 ; 424277 ; 544 587 ; 544 85 ; 544124 ; 544131 ; 544145 ; 544357 ; 544360 ; 544379 ; 546187 ; 546193 ; 546207 ; 546281 ; 546284 ; 548527 ; 546214 ;
Abstract

New compounds of the formula: ##STR1## wherein X.sup..crclbar. is an anion, R is (C.sub.1-7) alkyl [unsubstituted or substituted by hydroxy, carboxy, alkoxycarbonyl, cyano, dialkylamino, alkylcarbonyl, or benzoyl which is unsubstituted or substituted by one or more halogen atoms or radicals selected from alkyl (optionally substituted by one or more halogens), alkoxy, hydroxy, amino, alkylamino, dialkylamino, cyano and nitro, or by a thenoyl radical (which is unsubstituted or substituted by one or more halogens or radicals selected from alkyl, cyano and nitro), or a pyridinecarbonyl, carbamoyl or dialkylcarbamoyl radical (the alkyl radicals of which can form a 5-membered or 6-membered heterocyclic ring) or a pyridyl radical], dialkylcarbamoyl (the alkyl radicals of which can form a 5-membered or 6-membered heterocyclic ring), (C.sub.2-4) alkenyl, (C.sub.2-4) alkynyl, alkoxycarbonyl or a 2-oxotetrahydrofuran-3-yl or 2-oxotetrahydropyran-3-yl ring, and either R.sub.1 and R.sub.2 are phenyl, cycloalkyl, alkyl or phenylalkyl or together form a 5-membered to 7-membered heterocyclic ring, or R.sub.1 is phenyl optionally substituted by one or more halogen atoms or radicals selected from alkyl optionally substituted by one or more halogens, alkoxy, hydroxy, amino, alkylamino, dialkylamino, cyano and nitro, or alternatively is cycloalkyl, alkyl or phenylalkyl, and R.sub.2 is a hydrogen atom, are useful as cytoprotective anti-ulcer agents.


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