The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 28, 1983
Filed:
Jul. 14, 1980
James H Carter, II, Ft. Lauderdale, FL (US);
Coulter Electronics, Inc., Hialeah, FL (US);
Abstract
Biological cell compositions are stabilized to preserve aldehyde functionality by formation of acetal, particularly cyclic acetal, primarily in order to prevent cell-to-cell crosslinking. The stabilized biological cells are particularly useful as human blood particle analogs in reference reagents employed in electronic hematology testing instrumentation. A process for preparing the acetal-stabilized biological cells employs reaction of polyaldehyde-treated biological cells with alcohol, preferably including 1,2 dialcohol, under acidic conditions; thereafter, the resulting product solution is adjusted to basic condition, stabilizing the acetal formation on the biological cells.