The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 14, 1983
Filed:
Mar. 04, 1981
Marco Falciani, Milan, IT;
Renato Broggi, Milan, IT;
Dobfar S.p.A., Milan, IT;
Abstract
Cephalosporine desacetoxy esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R.sub.1 is selected from the group consisting of ##STR3## Such esters and salts thereof having antibiotic activity are prepared by reacting 7-ADCA with bromophthalide or chloromethyl pivalate in the presence of an alkylamine at a temperature in the range of 0.degree.-70.degree. C. The reaction product is reacted with chloride chlorohydrate of D(-)dihydrophenylglycine or D(-)p-hydroxy phenylgycine. A salt of the compound of formula (I) is isolated from the reaction mixture, which after washing with acidic water and addition of a pharmaceutically acceptable acid is obtained by treatment with suitable solvent.