The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 23, 1982
Filed:
Aug. 28, 1980
Teijin Limited, Osaka, JP;
The Chemo-Sero-Therapeutic Research Institute, Kumamoto, JP;
Abstract
The present invention is directed to an S-sulfonated immunoglobulin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7. There is also provided a process for producing an S-sulfonated immunoglobulin composition having a high monomer content, which comprises contacting an S-sulfonated immunoglobulin in aqueous solution with about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of the water-soluble acid addition salt, or reacting an immunoglobulin in aqueous solution with a compound capable of yielding a sulfite ion in water and an oxidizing agent in the presence of about 1 to about 600% by weight, based on the immunoglobulin, of the water-soluble acid addition salt.