The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Nov. 16, 1982

Filed:

Apr. 09, 1981
Applicant:
Inventors:

Lester J Kaplan, Kalamazoo, MI (US);

Moses W McMillan, Portage, MI (US);

Jacob Szmuszkovicz, Kalamazoo, MI (US);

Assignee:

The Upjohn Company, Kalamazoo, MI (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D / ; A61K / ;
U.S. Cl.
CPC ...
424274 ; 548407 ; 549 39 ; 549333 ; 2603303 ; 546 15 ; 546230 ; 546231 ; 546234 ; 424244 ; 424267 ; 424275 ; 424278 ; 424304 ; 424309 ; 424311 ; 424324 ; 564155 ; 564162 ; 564163 ; 564166 ; 560 16 ; 560251 ;
Abstract

N-[2-Amino(oxy or thio group) substituted-cycloaliphatic]phenylacetamide and -benzamide compounds, having the oxy- or thio group substituents on a cycloaliphatic ring carbon adjacent to either of the nitrogen bearing carbons of the cycloaliphatic ring, e.g., cis- and trans-4-bromo-N-[3-methoxy-2-(1-pyrrolidinyl)cyclohexyl]-N-methylbenzamide , and trans-3,4-dichloro-N-methyl-N-[7-(1-pyrridolinyl)-1,4-dioxaspiro[4.5]dec-6 -yl]benzeneacetamide, and salts thereof, have useful analgesic activity and low abuse liability in humans and valuable warm blooded animals. Processes for their production and pharmaceutical compositions and method of use are also disclosed.


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